Keep in mind though that this research is often government subsidized, and sometimes by multiple countries.

The price of biologics kills me. I know it costs about $20 dollars for a month of GLP-1 agonists, because I’ve made similar peptides myself in grad school. Something like a Solid Phase Peptide Synthesizer runs $10-250K, but the cost to synthesize a 40 amino acid linear peptide at industrial scale is like…$0.30 USD per milligram. Shorter chain peptides are even cheaper. A 15AA linear peptide can be as low as $0.01/mg.

There are of course other expenses, especially labor, facilities, certification, and waste disposal, but these companies are still easily making 40-50% profit margins on biologics. Compare this to non-biologics pharmaceutical profit margins around 15-25%, or for other industry comparisons, grocery stores around 1-3%, restaurants 3-10%, and software at 15-20%.

One of ours does this. I object, so I just breeze past the security guard without listening or making eye contact.

I still remember the rage I felt when I first realized that the United States justice system is fundamentally adversarial. Prosecuting attorneys don’t want to find the truth of the matter. The build the strongest case possible and it’s on the defendant to prove they’re wrong. Attorneys are supposed to take into account all available evidence, but have no obligation to seek additional information that could exonerate the defendant, even if it’s clear such information exists.

It’s absolutely fucked.

I’ve been gambling before and it was fun when I won money. The thing is I know how, with few exceptions with games like poker and blackjack (and only then if you’re skilled), you will ALWAYS lose more money than you win over long enough of a time period.

I’m a big, walking math machine, though, so I’ve been the person getting a little too tipsy at the roulette table and telling everyone exactly how probability works and that numbers are never “hot”. The roulette dealer was surprisingly amused.

OMG this is great. Thanks for the recommendation!

Yep, it’s all cumulative. I think the “weight loss is in the kitchen” advice helps those who don’t understand weight loss is a function of net calories, so start exercising and eat more because they think exercise somehow magically makes weight go away. If only I had a nickel for every time I heard “weight lifting converts fat into muscle” over the years…

My aunt is a great example. She started doing daily walks to lose weight but picked up a “healthy protein smoothie” from a local coffee shop on the way home. She slowly gained weight because they were more like milkshakes and easily had 500+ calories per serving.

There is at least one TV application that doesn’t support local streaming without first logging into Plex’s servers. I have an LG tv and it’ll hang at the loading screen, then error out if I don’t have Internet connectivity. I love the TV but LG as a company sucks. I wouldn’t buy it again.

Given we have the technology, any new construction should be required to be environmentally neutral at a minimum, ideally with ongoing improvement.

If they need to use millions of gallons of groundwater? Great, go fucking wild, but directly fund managed aquifer recharge projects to replace that groundwater at an equal or greater rate.

Increases in resource consumption should be covered entirely by the data center plus improvements to benefit the community.

No longer should big business be used as a means to siphon the value of labor and natural resources and concentrate it for selfish use by the worst of humanity.

If you genuinely want to change and find a therapist who can help you find the right resources to do it, it’s invaluable.

One of my motherboard’s memory slots went bad, no idea why. Figuring out if it was RAM or, if the motherboard, exactly what was wrong, was a tense few hours because neither is getting replaced.

100% right on for me. It took me years, YEARS, to get my mother to where she would check if USB peripherals were plugged in before asking me to come over and find out why it was broken. Even the occasional slight complications with Plex get her to where she doesn’t use it for months unless I fix it for her. Jellyfin just ain’t happening with her.

I thought that was a golden calf, not a jackass.

Plus the article itself is primarily dramatic fluff writing, followed by something I loathe: quotations from social media reactions. I’d love for anyone that does like them to share why because I cannot see the utility.

Pretty much. My grandmother made something called tater tot casserole: a mix of ground beef, frozen tater tots, canned beans, and mystery spices that went stale sometime in the last ice age. This was covered with about half a kilo of cheese and baked until a point she couldn’t quite articulate but “just knew”.

If you have legionella in your hot water, the issue isn’t going to come from drinking it, but inhaling it when you shower. As long as you don’t have a dead leg in your water system or a circuit that stagnates for long periods of time, legionella is pretty much a non-issue in the vast majority of homes, even older homes.

Extra tasty ham loaf… as opposed to a regularly tasty ham loaf? Huh.

I had an elderly aunt that made “oyster stew” on special occasions. The recipe was as follows:

One gallon of 2% milk
One 16 oz. jar raw oysters with juice
Salt and pepper to taste

That’s literally all that was in it. She’d mix it together, heat until steaming, then serve. Just a big pot of hot, oyster scented, salty milk, served with oyster crackers. Everyone hated it and none of her children carried on the tradition.

That recipe deserved to die.

Edit: oops, broken line breaks.

I started young with the Muppet Learning Keys and Discovery Disk. I loved the AD&D games: Pool of Radiance, Curse of the Azure Bonds, and Champions of Krynn. We didn’t have an NES, so there was… The Great Giana Sisters. Ultima IV: Quest of the Avatar was great.

I might like CRPGs.

They’re not the brightest, which we all know tends to correlate strongly with conservatism. I’ll always remember the idiots in 2004 who voted for a second W. Bush term because “he made this mess, now he needs to clean it up”.

That’s like hiring an incompetent employee who messed up a mission-critical project and not only took no accountability, but verifiably lied about their actions, yet you continue employing them to finish the project.